Thymalin

Research overview

Thymalin is a thymus-derived peptide preparation, described in the literature as a thymic peptide complex and also listed as Thymus Peptide Complex. It is studied for immune regulation, cell differentiation and age-related signalling in cell and preclinical models. Supplied at 10mg as a lyophilised powder for in-vitro laboratory research only.

Thymic peptide preparations were developed from animal thymus tissue and are described as regulators of T-lymphocyte maturation. Thymalin has been reported in the literature to influence T-cell differentiation, cytokine release and, in long-term animal studies of ageing, markers of immune and neuroendocrine function. Mechanistic detail is limited, much of the work comes from a small number of groups, and the exact composition of preparations called thymalin varies between sources.

In the laboratory it is used in lymphocyte culture assays that follow proliferation, differentiation markers and cytokine release, and in analytical work to characterise complex peptide mixtures. Because the literature describes thymalin as a peptide complex, identity and content are best confirmed by HPLC and mass spectrometry before use. It is supplied as a lyophilised powder.

Research areas

• T-lymphocyte differentiation in culture
• Cytokine release in immune cell models
• Thymic peptide signalling in ageing models
• Characterisation of complex peptide preparations
• HPLC and mass spectrometry identity checks

Specifications

CAS number

63958-90-7

Molecular formula

C33H54N12O15

Molecular weight

858.86 g/mol

Form

lyophilised powder

Purity

≥99% (HPLC)

Also known as

Thymalin, Thymus Peptide Complex, Thymic Peptide Preparation

Supplied as

10mg per vial, lyophilised powder

Storage and handling

Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent, aliquot, and keep reconstituted material cold.

Certificates of analysis

Each lot of Thymalin is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.

Questions