B7-33

Name: B7-33 6mg
Brand: LABS PTG
SKU: PTG-B733-6MG
Price: 49.90 GBP
Availability: InStock

6mg lyophilised powderCAS 1818415-56-3

A single-chain relaxin-derived peptide used to probe RXFP1 receptor pharmacology and fibrosis models in heart, kidney, lung and liver cells.

£49.90per vial, VAT included

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Batch certificate in the COA Database

Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.

Research overview

B7-33 is a 27-residue single-chain peptide based on the B-chain of human relaxin-2, with the sequence VIKLSGRELVRAQIAISGMSTWSKRSL. It is used to probe RXFP1 receptor pharmacology and fibrosis models in heart, kidney, lung and liver cells. Supplied at 6mg as a lyophilised powder for in-vitro laboratory research only.

Relaxin-2 is a two-chain peptide hormone that signals through RXFP1, a G protein-coupled receptor. B7-33 keeps only a shortened B-chain region and has no A-chain, which makes it simpler to synthesise. It is described in the literature as a functionally selective agonist, reported to favour ERK phosphorylation over cAMP accumulation. That bias is the reason it is studied, since the antifibrotic signalling of relaxin is thought to run mainly through the ERK-linked route.

Typical assays use RXFP1-expressing HEK293 cells for cAMP and ERK readouts, and primary fibroblasts or myofibroblasts from heart, kidney, lung or liver for collagen deposition and matrix gene expression. Comparison with full-length relaxin helps define biased signalling and the contribution of the missing A-chain. The peptide is supplied as a lyophilised powder in a 6mg vial.

Research areas

RXFP1 receptor pharmacology
Biased signalling: ERK versus cAMP pathways
Fibroblast collagen deposition assays
Matrix gene expression in cardiac, renal and lung cells
Comparison with full-length relaxin-2

Specifications

CAS number: 1818415-56-3
Molecular formula: C131H229N41O36S
Molecular weight: 2986.58 g/mol
Sequence: VIKLSGRELVRAQIAISGMSTWSKRSL (27-mer, relaxin B-chain analogue)
Form: lyophilised powder
Purity: ≥99% (HPLC)
Also known as: B7-33; single-chain relaxin-2 (H2) B-chain analogue; functionally selective RXFP1 agonist; relaxin mimetic peptide
Supplied as: 6mg per vial, lyophilised powder

Storage and handling

Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial warm to room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.

Certificates of analysis

Each lot of B7-33 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.

Questions

How does B7-33 differ from relaxin?

Relaxin-2 has an A-chain and a B-chain. B7-33 is a single-chain peptide based on part of the B-chain alone, and it is described as a functionally selective RXFP1 agonist rather than a full mimic of the hormone.

How is B7-33 supplied and stored?

It is a lyophilised powder in a 6mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.

Is B7-33 a medicine?

No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.