TB-500

Name: TB-500 5mg
Brand: LABS PTG
SKU: PTG-TB500-5MG
Price: 18.40 GBP
Availability: InStock

5mg lyophilised powder

A short acetylated fragment of thymosin beta-4 containing its actin-binding motif, used in actin dynamics, cell migration and tissue-repair signalling work.

£18.40per vial, VAT included

In stock, dispatched same day before 16:00

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Batch certificate in the COA Database

Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.

Research overview

TB-500 is a short acetylated peptide, Ac-LKKTETQ, corresponding to residues 17 to 23 of thymosin beta-4, the region that contains its actin-binding motif. It is used in actin dynamics, cell migration and tissue-repair signalling work. Supplied at 5mg as a lyophilised powder for in-vitro laboratory research only.

Thymosin beta-4 is a small intracellular protein that binds monomeric actin and helps regulate the pool available for filament assembly. The LKKTET region is described as the actin-binding site, and the shorter fragment is used to ask which activities of the full protein depend on that region. Reports in cell and preclinical models describe effects on cell migration, endothelial behaviour and inflammatory signalling, although how much of this is reproduced by the fragment alone has been questioned.

Typical work includes actin polymerisation assays with purified proteins, scratch-wound and transwell migration assays in endothelial cells and keratinocytes, and fluorescence imaging of the actin cytoskeleton. The name TB-500 is used elsewhere for more than one thymosin beta-4 related material, so the sequence given on this page should be checked against other papers. It is supplied as a lyophilised powder.

Research areas

Actin monomer binding and filament assembly
Cell migration in scratch-wound and transwell assays
Endothelial cell behaviour in culture
Cytoskeleton imaging by fluorescence microscopy
Thymosin beta-4 fragment structure-activity work

Specifications

Molecular formula: C38H68N10O14
Molecular weight: ~889.0 g/mol
Sequence: Ac-LKKTETQ (thymosin beta-4 residues 17-23, N-acetylated)
Form: lyophilised powder
Purity: ≥99% (HPLC)
Also known as: TB-500, TB-500 fragment, Ac-LKKTETQ, thymosin beta-4 (17-23) fragment
Supplied as: 5mg per vial, lyophilised powder

Storage and handling

Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial warm to room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.

Certificates of analysis

Each lot of TB-500 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.

Questions

How does TB-500 differ from thymosin beta-4?

Thymosin beta-4 is the full-length protein. TB-500, as listed here, is a short N-acetylated fragment covering residues 17 to 23, the region that contains the actin-binding motif.

What form is TB-500 supplied in?

It is a lyophilised powder in a 5mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.

Is TB-500 a medicine?

No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.