≥99% HPLCBatch testedIdentity by MS, purity by HPLC
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Semax
5mg lyophilised powderCAS 80714-61-0
A synthetic ACTH-fragment analogue studied in neurotrophin signalling, neuronal plasticity and stress-related pathways.
£19.00per vial, VAT included
In stock, dispatched same day before 16:00
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- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), built from the ACTH(4-7) fragment with a Pro-Gly-Pro tail. It is studied in neurotrophin signalling, neuronal plasticity and stress-related pathways in cell and preclinical models, and it is a common reference for ACTH-fragment peptide design. Supplied at 5mg as a lyophilised powder for in-vitro laboratory research only.
The ACTH(4-7) fragment contains the sequence Met-Glu-His-Phe and is described as lacking the hormonal activity of full-length ACTH. The Pro-Gly-Pro extension is intended to slow peptidase breakdown. In rodent studies and neural cell cultures, Semax has been reported to change expression of BDNF and its receptor TrkB, and of other genes involved in neuronal plasticity and stress responses. Much of this work was published by one research group, and the receptor mechanism is not settled.
Researchers use it in neuronal and glial cultures for BDNF and TrkB expression assays, in neurite outgrowth and survival assays under stress, and in gene expression profiling by qPCR and transcriptomics. Comparison with other ACTH-derived peptides and with Selank is common. It is supplied as a lyophilised powder in a 5mg vial.
Research areas
- BDNF and TrkB expression in neural cultures
- Neurite outgrowth and survival under stress
- Neuronal plasticity gene expression
- ACTH fragment structure-activity work
- Peptidase resistance of Pro-Gly-Pro extended peptides
Specifications
- CAS number
- 80714-61-0
- Molecular formula
- C37H51N9O10S
- Molecular weight
- ~813.92 g/mol
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- One-letter code
- MEHFPGP
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- Semax, ACTH(4-7) Pro-Gly-Pro, Met-Glu-His-Phe-Pro-Gly-Pro
- Supplied as
- 5mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of Semax is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What is the difference between Semax and ACTH?
ACTH is a large pituitary hormone. Semax is built from just four residues of it, ACTH(4-7), plus a Pro-Gly-Pro tail, and it is described as lacking the hormonal activity of the full molecule.
How is Semax supplied and stored?
It is supplied as a lyophilised powder in a 5mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is Semax a medicine?
No. The material sold here is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Neuro and signalling
Studied alongside
