DSIP

Research overview

DSIP, or delta sleep-inducing peptide, is a naturally occurring nonapeptide with the sequence WAGGDASGE, first described in the 1970s. It is studied as a neuropeptide in sleep, stress and neuroendocrine signalling models, in neuronal cultures as well as in preclinical work. Supplied at 5mg as a lyophilised powder for in-vitro laboratory research only.

DSIP was named for its reported ability to promote delta-wave sleep in rabbits. Decades of work have not identified a dedicated DSIP receptor or gene product, and the peptide's endogenous role remains uncertain. Reported actions in the literature include modulation of the stress axis, effects on neurotransmitter systems such as GABA and glutamate, and interaction with NMDA-type receptors in neuronal preparations. The peptide is also known to be broken down quickly by peptidases, which complicates interpretation.

Researchers use it in electrophysiology and calcium imaging with neuronal cultures and brain slices, in neuroendocrine assays of stress-hormone release from pituitary or hypothalamic preparations, and in peptide degradation studies by HPLC. Its short sequence also makes it a convenient model for peptidase specificity work. It is supplied as a lyophilised powder in a 5mg vial.

Research areas

• Neuropeptide signalling in neuronal cultures
• Stress-axis hormone release in hypothalamic models
• NMDA and GABA receptor interactions
• Peptidase degradation and stability
• Preclinical sleep-regulation models

Specifications

CAS number

62568-57-4

Molecular formula

C35H48N10O15

Molecular weight

~848.82 g/mol

Sequence

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

One-letter code

WAGGDASGE

Form

lyophilised powder

Purity

≥99% (HPLC)

Also known as

DSIP, Delta Sleep-Inducing Peptide, Delta sleep peptide

Supplied as

5mg per vial, lyophilised powder

Storage and handling

Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.

Certificates of analysis

Each lot of DSIP is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.

Questions