Selank

Research overview

Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP), modelled on the immune peptide tuftsin. It is studied in GABAergic modulation, neuropeptide signalling and neuroimmune interactions in cell and preclinical models, and its sequence joins an immune peptide to a stabilising tail. Supplied at 5mg as a lyophilised powder for in-vitro laboratory research only.

Selank combines the tuftsin sequence Thr-Lys-Pro-Arg with a Pro-Gly-Pro tail intended to resist peptidases. Tuftsin is an immunomodulatory tetrapeptide, and Selank is studied in the literature for effects on interleukin expression, on enkephalin-degrading enzymes and on GABAergic and serotonergic markers in rodent brain tissue. Reported mechanisms, including allosteric modulation of GABA-A receptors, come mostly from a small number of research groups and are still being tested.

Laboratory use includes gene expression assays for cytokines and neurotrophic factors in cultured immune and neural cells, enkephalinase activity assays, GABA-A receptor binding and electrophysiology in neuronal preparations, and peptide stability studies in serum-containing media that follow how quickly the Pro-Gly-Pro tail protects the intact sequence. It is supplied as a lyophilised powder in a 5mg vial.

Research areas

• GABA-A receptor modulation in neuronal preparations
• Interleukin expression in immune cell models
• Enkephalin-degrading enzyme assays
• Neurotrophic factor gene expression
• Stability of tuftsin-derived peptides

Specifications

CAS number

129954-34-3

Molecular formula

C33H57N11O9

Molecular weight

~751.9 g/mol

Sequence

Thr-Lys-Pro-Arg-Pro-Gly-Pro

One-letter code

TKPRPGP

Form

lyophilised powder

Purity

≥99% (HPLC)

Also known as

Selank, Thr-Lys-Pro-Arg-Pro-Gly-Pro

Supplied as

5mg per vial, lyophilised powder

Storage and handling

Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.

Certificates of analysis

Each lot of Selank is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.

Questions