≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
PT-141
10mg lyophilised powderCAS 189691-06-3
A cyclic melanocortin receptor agonist used to study MC3R and MC4R signalling and central neuropeptide pathways.
£16.99per vial, VAT included
In stock, dispatched same day before 16:00
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- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
PT-141 is a cyclic heptapeptide melanocortin-receptor agonist, Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys), described as a Melanotan II analogue. It is used to study MC3R and MC4R signalling, receptor selectivity across the melanocortin family and central neuropeptide pathways in cell-based assays. Supplied at 10mg as a lyophilised powder for in-vitro laboratory research only.
The melanocortin system comprises five G protein-coupled receptors, MC1R to MC5R, activated by peptides derived from pro-opiomelanocortin. PT-141 has a lactam bridge between the Asp and Lys side chains, which constrains its structure, and a D-phenylalanine that improves resistance to proteolysis. It is described as an agonist with activity across several melanocortin receptors, most often studied at MC3R and MC4R, where it raises cAMP in receptor-expressing cells.
Laboratory work includes cAMP accumulation and receptor-binding assays in HEK293 cells expressing individual melanocortin receptors, selectivity profiling across MC1R to MC5R, and structure-activity comparisons against Melanotan II and linear melanocortin peptides. Cyclic lactam peptides are also used to test conformational stability. It is supplied as a lyophilised powder in a 10mg vial.
Research areas
- MC3R and MC4R agonism and cAMP signalling
- Receptor selectivity across MC1R to MC5R
- Lactam-bridged cyclic peptide structure
- Comparison with Melanotan II analogues
- Central neuropeptide pathway models
Specifications
- CAS number
- 189691-06-3
- Molecular formula
- C50H68N14O10
- Molecular weight
- ~1025.18 g/mol
- Sequence
- Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys) (cyclic lactam; contains D-Phe)
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- PT-141, Melanotan II analogue
- Supplied as
- 10mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of PT-141 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
How is PT-141 related to Melanotan II?
PT-141 is described as a Melanotan II analogue. Both are cyclic lactam melanocortin peptides with closely related structures, and their receptor activity profiles are often compared.
How is PT-141 supplied and stored?
It is supplied as a lyophilised powder in a 10mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is PT-141 a medicine?
No. The material sold here is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Neuro and signalling
Studied alongside
