Growth axis
CJC-1295 with DAC
A GHRH 1-29 analogue carrying a drug-affinity-complex modification for longer persistence
£20.902mg
≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
PEG-MGF
2mg lyophilised powderCAS 108174-48-7
A PEG-modified version of the IGF-1 splice-variant peptide MGF, used to look at growth-factor signalling and the effect of PEGylation on stability.
£19.90per vial, VAT included
In stock, dispatched same day before 16:00
- Free shipping on UK orders over £20.00
- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
PEG-MGF is the 24-residue mechano growth factor peptide carrying a polyethylene glycol (PEG) group at its N-terminus. It is used to look at IGF-1 splice-variant signalling and at how PEGylation affects the stability of the peptide. Supplied at 2mg as a lyophilised powder for in-vitro laboratory research only.
PEGylation attaches polyethylene glycol chains to a peptide to increase its hydrodynamic size. In the wider peptide literature this is reported to slow enzymatic degradation and clearance. For MGF, the question studied is whether the E-domain peptide keeps its activity in myogenic cell models once it carries a PEG group, and how long it stays intact in media compared with the unmodified peptide. Published data on this specific compound are limited.
Laboratory use includes side-by-side stability assays against unmodified MGF, mass spectrometry and size-exclusion chromatography to characterise PEGylated species, and myoblast proliferation and signalling assays run alongside the unmodified peptide. The formula and weight listed for this product describe the peptide backbone only and exclude the PEG group. It is supplied as a lyophilised powder.
Research areas
- Effect of PEGylation on peptide stability
- Mass spectrometry and size-exclusion characterisation
- Myoblast proliferation and signalling assays
- IGF-1 splice-variant E-domain biology
- Conjugation chemistry of short peptides
Specifications
- CAS number
- 108174-48-7
- Molecular formula
- C121H200N42O39 (peptide backbone; excludes PEG)
- Molecular weight
- 2867.2 (peptide backbone; excludes PEG)
- Sequence
- YQPPSTNKNTKSQRRKGSTFEERK (peptide backbone; N-terminally PEGylated)
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- PEG-MGF, Pegylated Mechano Growth Factor, PEGylated IGF-1 Ec splice variant, PEG-IGF-1 Ec
- Supplied as
- 2mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder cold, dry and protected from light, and allow the vial to reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of PEG-MGF is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What does the PEG group change compared with MGF?
The peptide backbone is the same 24 residues. The PEG group increases molecular size and is investigated for its effect on stability and persistence in media. The formula and weight listed refer to the backbone, not to the PEGylated product.
How should PEG-MGF be stored?
It is supplied as a lyophilised powder in a 2mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is PEG-MGF a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Growth axis
Studied alongside
