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Growth axis

GHRP-2

10mg lyophilised powderCAS 158861-67-7

A hexapeptide that releases growth hormone, used to study ghrelin-receptor activation in the hypothalamic-pituitary axis.

£9.99per vial, VAT included

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Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.

Research overview

GHRP-2 is a synthetic hexapeptide with the sequence D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys and a C-terminal amide, also listed as KP-102. It belongs to the growth-hormone-releasing peptide class and is studied in vitro and in preclinical models for ghrelin-receptor activation in the hypothalamic-pituitary axis. Supplied at 10mg for in-vitro laboratory research only.

GHRP-2 acts as an agonist at the growth hormone secretagogue receptor 1a (GHS-R1a), the receptor for the natural peptide ghrelin. The receptor couples mainly through Gq, raising intracellular calcium and activating protein kinase C. Reports describe GHRP-2 as acting at both pituitary and hypothalamic sites, through a pathway distinct from that of growth-hormone-releasing hormone. In cell models its activity is read as calcium mobilisation and downstream hormone release.

Laboratory work includes receptor-binding competition assays, calcium-flux and inositol phosphate assays in cells expressing GHS-R1a, and hormone release measurements in primary pituitary cultures. It is also used as a reference ligand when comparing secretagogue analogues, and in studies of how receptor signalling changes after repeated exposure. The compound is supplied as a lyophilised powder in a 10mg vial.

Research areas

  • GHS-R1a binding and activation
  • Calcium mobilisation in receptor-expressing cells
  • Hypothalamic-pituitary signalling models
  • Comparison of secretagogue peptide analogues
  • Receptor desensitisation and trafficking studies

Specifications

CAS number
158861-67-7
Molecular formula
C45H55N9O6
Molecular weight
~818.0 g/mol.
Sequence
D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 (C-terminal amide)
Form
lyophilised powder
Purity
≥99% (HPLC)
Also known as
GHRP-2, Growth Hormone Releasing Peptide-2, KP-102.
Supplied as
10mg per vial, lyophilised powder

Storage and handling

Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.

Certificates of analysis

Each lot of GHRP-2 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.

Questions

How is GHRP-2 related to GHRP-6?

Both are synthetic hexapeptides of the growth-hormone-releasing peptide class and both act at GHS-R1a. They differ in sequence: GHRP-2 contains D-Ala and D-2-Nal residues, while GHRP-6 contains His and D-Trp. Their pharmacology is often compared in the literature.

How is GHRP-2 supplied?

It is supplied as a lyophilised powder in a 10mg vial. Keep it cold, dry and away from light until it is needed, then reconstitute with a suitable laboratory diluent.

Is GHRP-2 a medicine?

No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.

GHRP-2 10mg
£9.99

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