HGH Frag 176-191

Research overview

HGH Frag 176-191 is the C-terminal stretch of human growth hormone, a 16-residue peptide with the sequence YLRIVQCRSVEGSCGF. It is studied in vitro and in preclinical models for fragment-specific receptor interactions and metabolic pathways. Supplied at 2mg as a lyophilised powder for in-vitro laboratory research only.

The 176-191 region sits at the C-terminus of growth hormone. It has been examined as a fragment that may retain some of the metabolic activity reported for the full protein while lacking its growth-promoting and insulin-antagonising effects. The literature describes experiments in adipocyte models that measure lipolysis and lipogenesis. The mechanism is not settled, some reports point to signalling independent of the classical growth hormone receptor, and published findings differ between models.

Researchers use the fragment in adipocyte culture assays that follow glycerol release and lipid uptake, in receptor-binding comparisons with intact growth hormone, and in peptide stability studies that follow the two cysteines and their disulfide behaviour. It is often compared with AOD9604, a closely related fragment analogue. The compound is supplied as a lyophilised powder.

Research areas

• Lipolysis and lipogenesis in adipocyte cultures
• Fragment-specific growth hormone receptor interactions
• Receptor-independent metabolic signalling hypotheses
• Peptide stability and disulfide behaviour
• Comparison with AOD9604 and intact growth hormone

Specifications

CAS number

66004-57-7

Molecular formula

C78H125N23O23S2

Molecular weight

~1817.12 g/mol

Sequence

YLRIVQCRSVEGSCGF (hGH residues 176-191)

Form

lyophilised powder

Purity

≥99% (HPLC)

Also known as

HGH Frag 176-191, hGH Fragment 176-191, Modified hGH C-terminal fragment

Supplied as

2mg per vial, lyophilised powder

Storage and handling

Store the lyophilised powder cold, dry and protected from light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent, aliquot, and keep reconstituted material cold.

Certificates of analysis

Each lot of HGH Frag 176-191 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.

Questions