≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
GHK-CU
50mg lyophilised powderCAS 49557-75-7
A copper-binding tripeptide complex studied for copper transport, extracellular-matrix regulation and copper-dependent cell signalling.
£15.99per vial, VAT included
In stock, dispatched same day before 16:00
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- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
GHK-CU is a copper(II) complex of the tripeptide Gly-His-Lys (GHK), also listed as Copper Tripeptide-1. It is studied for copper transport, extracellular-matrix regulation and copper-dependent cell signalling in cultured fibroblasts and other cells, and in spectroscopic work on the complex. Supplied at 50mg as a lyophilised powder for in-vitro laboratory research only.
GHK was first reported as a copper-binding factor in human plasma, and it forms a stable complex with copper(II) through the N-terminal amine, a backbone nitrogen and the histidine side chain. In the literature GHK-CU is described as a copper carrier that can deliver the metal to cells and influence copper-dependent enzymes such as lysyl oxidase. Fibroblast culture studies report changes in collagen, glycosaminoglycan and matrix metalloproteinase expression, and gene-expression database analyses have suggested broad effects on gene sets linked to tissue remodelling.
Researchers use it in fibroblast and keratinocyte cultures that measure collagen, glycosaminoglycan and matrix metalloproteinase expression, in scratch-wound migration assays, in copper-uptake studies and in spectroscopic work on the complex itself (UV-visible, circular dichroism and EPR). Comparisons with the copper-free peptide and with AHK-Cu help separate the role of copper from that of the sequence.
Research areas
- Copper(II) transport and delivery in cell cultures
- Collagen and glycosaminoglycan expression in fibroblasts
- Matrix metalloproteinase regulation
- Scratch-wound migration assays
- Gene-set analysis of tissue-remodelling pathways
Specifications
- CAS number
- 49557-75-7
- Molecular formula
- C14H22CuN6O4
- Molecular weight
- 403.92 g/mol
- Sequence
- Gly-His-Lys (GHK), copper(II) complex
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- GHK-Cu, Copper Tripeptide-1, Glycyl-L-histidyl-L-lysine copper complex
- Supplied as
- 50mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder cold, dry and protected from light, with the container tightly closed. Avoid strong chelating agents when preparing solutions, since they can strip the copper from the peptide.
Certificates of analysis
Each lot of GHK-CU is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What does the Cu in GHK-CU stand for?
Cu is the chemical symbol for copper. GHK-CU is the tripeptide Gly-His-Lys bound to a copper(II) ion. The copper-free peptide, GHK, is studied alongside it to separate the role of the metal.
How is GHK-CU supplied and stored?
It is supplied as a lyophilised powder in a 50mg container. Keep it cold, dry and away from light, and prepare solutions only when the material is needed.
Is GHK-CU a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food, supplement or cosmetic ingredient, and it is not for human or animal use. Buyers must be aged 18 or over.
Skin and matrix
Studied alongside
Skin and matrix
PTD-DBM
A cell-penetrating peptide built to interrupt a CXXC5-Dishevelled contact
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