≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
SS-31
10mg lyophilised powderCAS 736992-21-5
A tetrapeptide that targets mitochondria, studied for cardiolipin binding, bioenergetics and oxidative-stress handling in cells.
£26.99per vial, VAT included
In stock, dispatched same day before 16:00
- Free shipping on UK orders over £20.00
- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
SS-31 is a mitochondria-targeting tetrapeptide, D-Arg-Dmt-Lys-Phe-NH2, where Dmt is 2',6'-dimethyl-L-tyrosine. It is studied in cells and isolated mitochondria for cardiolipin binding, bioenergetics and the handling of oxidative stress, and is built from alternating aromatic and basic residues with a C-terminal amide. Supplied at 10mg as a lyophilised powder for in-vitro laboratory research only.
The Szeto-Schiller peptides alternate aromatic and basic residues, giving them a positive charge that is reported to let them cross cell membranes without a transporter and accumulate in mitochondria. SS-31 is described as binding cardiolipin, a phospholipid concentrated in the inner mitochondrial membrane. The proposed outcome is stabilisation of cristae structure and of electron transport complex organisation, with less formation of reactive oxygen species under stress.
Researchers use it in isolated mitochondria and in cultured cardiomyocyte, neuronal and kidney cell models, where it is tested against oxidative or ischaemia-like stress. Common readouts are oxygen consumption, membrane potential dyes, reactive oxygen species probes and electron microscopy of cristae. It is supplied as a lyophilised powder in a 10mg vial.
Research areas
- Cardiolipin binding and membrane biophysics
- Mitochondrial respiration in isolated organelles
- Oxidative-stress responses in cardiomyocyte cultures
- Cristae structure by electron microscopy
- Organelle-targeting peptide design
Specifications
- CAS number
- 736992-21-5
- Molecular formula
- C32H49N9O5
- Molecular weight
- 639.8
- Sequence
- D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2′,6′-dimethyl-L-tyrosine; D-Arg; C-terminal amide)
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- SS-31
- Supplied as
- 10mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial warm to room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of SS-31 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What does the Dmt residue do?
Dmt is 2',6'-dimethyl-L-tyrosine, a modified tyrosine reported to give the peptide antioxidant character and resistance to enzymatic breakdown. With the D-arginine, it sets SS-31 apart from natural peptides.
How is SS-31 supplied and stored?
It is supplied as a lyophilised powder in a 10mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is SS-31 a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Metabolic
Studied alongside
