≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
5-Amino-1MQ
10mg crystalline powderCAS 42464-96-0
A small-molecule inhibitor of the enzyme NNMT, used to study methylation, NAD+ salvage and cellular energy metabolism.
£28.90per vial, VAT included
In stock, dispatched same day before 16:00
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- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
5-Amino-1MQ is a small quinolinium-based molecule, 5-amino-1-methylquinolinium, rather than a peptide. It is a reported inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT) and is used to study methylation, NAD+ salvage and cellular energy metabolism. Supplied at 10mg as a crystalline powder for in-vitro laboratory research only.
NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide and linking methyl-donor supply to the NAD+ salvage pathway. The enzyme is expressed at high levels in adipose tissue and in some tumour-derived cell lines. 5-Amino-1MQ is described in the literature as a membrane-permeable NNMT inhibitor, and in cultured adipocytes NNMT inhibition has been reported to change methyl-donor and NAD+ metabolite levels and lipid-handling gene expression.
Laboratory work includes NNMT enzyme inhibition assays with recombinant protein, LC-MS measurement of 1-methylnicotinamide, S-adenosylmethionine and NAD+ in cell cultures exposed to the compound, adipocyte differentiation assays, and selectivity comparisons against related methyltransferases, to check that inhibition is specific to NNMT. It is supplied as a crystalline powder in a 10mg container.
Research areas
- NNMT enzyme inhibition assays
- NAD+ salvage pathway metabolism
- Methyl-donor balance in cell cultures
- Adipocyte differentiation and lipid-handling gene expression
- Selectivity against related methyltransferases
Specifications
- CAS number
- 42464-96-0
- Molecular formula
- C10H11N2⁺
- Molecular weight
- ~159.21 g/mol
- Form
- crystalline powder
- Purity
- ≥99% (HPLC)
- Also known as
- 5-Amino-1-methylquinolinium, 5-Amino-1-MQ, NNMT inhibitor analog
- Supplied as
- 10mg per vial, crystalline powder
Storage and handling
Store the crystalline powder cold, dry and protected from light, with the container tightly closed. Dissolve in a laboratory solvent suited to the assay, and check solubility on a small amount first.
Certificates of analysis
Each lot of 5-Amino-1MQ is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
Is 5-Amino-1MQ a peptide?
No. It is a small organic cation, not a chain of amino acids. It is studied as a probe of the NNMT enzyme and is supplied as a crystalline powder.
How is it supplied and stored?
It is a crystalline powder in a 10mg container. Keep it cold, dry and away from light, and prepare solutions in a solvent suited to the assay only when needed.
Is 5-Amino-1MQ a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Metabolic
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