≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
Cagrilintide
5mg lyophilised powderCAS 1415456-99-3
A long-acting amylin analogue used to study amylin and calcitonin-receptor signalling in appetite and metabolic research.
£29.99per vial, VAT included
In stock, dispatched same day before 16:00
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- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
Cagrilintide is a long-acting analogue of amylin, a peptide hormone released alongside insulin, also listed as AM833. It is described as a dual amylin and calcitonin receptor agonist and is studied for receptor signalling in appetite and metabolic research. Supplied at 5mg as a lyophilised powder for in-vitro laboratory research only.
Amylin receptors form when the calcitonin receptor pairs with one of three receptor activity-modifying proteins, RAMP1, RAMP2 or RAMP3, giving the AMY1, AMY2 and AMY3 subtypes. Native amylin aggregates readily and is short-lived, so analogues have been engineered with changes designed to improve solubility and persistence. Cagrilintide is described in the literature as acting at both amylin and calcitonin receptors, and its signalling is read out mainly as cAMP accumulation in receptor-expressing cells.
Laboratory use includes cAMP and calcium assays in HEK293 or CHO cells co-expressing the calcitonin receptor with each RAMP, radioligand binding competition studies, and peptide aggregation and fibril formation work using thioflavin T fluorescence. It is also used in hypothalamic and brainstem neuron preparations for appetite-related signalling studies. It is supplied as a lyophilised powder in a 5mg vial.
Research areas
- Amylin receptor subtypes (calcitonin receptor with RAMPs)
- cAMP signalling in receptor-expressing cell lines
- Radioligand binding and receptor selectivity
- Peptide aggregation and fibril formation assays
- Appetite-related neuronal signalling models
Specifications
- CAS number
- 1415456-99-3
- Molecular formula
- C194H312N54O59S2
- Molecular weight
- 4409.01 g/mol
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- Cagrilintide, AM833, Long-acting amylin analogue, Dual amylin receptor agonist
- Supplied as
- 5mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of Cagrilintide is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What is cagrilintide an analogue of?
It is a long-acting analogue of amylin, a peptide hormone released alongside insulin from pancreatic beta cells. Native amylin aggregates easily, which is one reason engineered analogues are used in assays.
How is cagrilintide supplied and stored?
It is supplied as a lyophilised powder in a 5mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is cagrilintide a medicine?
No. The material sold here is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Metabolic
Studied alongside
