≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
Pancragen
20mg lyophilised powder
A short bioregulator-type peptide studied in pancreatic cell differentiation and survival models.
£40.90per vial, VAT included
In stock, dispatched same day before 16:00
- Free shipping on UK orders over £20.00
- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
Pancragen is a short bioregulator-type peptide, Lys-Glu-Asp-Trp (KEDW), described as a pancreatic peptide bioregulator. It is studied in pancreatic cell differentiation and survival models, within the family of very short peptides described largely by the Khavinson group. Supplied at 20mg as a lyophilised powder for in-vitro laboratory research only.
Pancragen is described as the pancreas-associated tetrapeptide of the bioregulator family. The proposed mechanism is entry into the nucleus and interaction with DNA or chromatin proteins, altering expression of genes in pancreatic cells. In islet-derived and pancreatic cell cultures, reported work includes changes in differentiation markers, proliferation and survival under stress. Evidence is limited to a small number of research groups, and mechanistic detail is still hypothetical.
Laboratory work uses pancreatic cell lines and islet cultures, with viability and proliferation assays, qPCR of differentiation and insulin-pathway genes, and immunostaining. Sources differ on whether the free acid or the amidated KEDW-NH2 is the literature compound, so identity should be confirmed by mass spectrometry. It is supplied as a lyophilised powder in a 20mg vial.
Research areas
- Pancreatic cell differentiation markers
- Survival under cell-stress conditions
- Islet-derived cell cultures
- Free acid versus amidated peptide comparison
- Gene expression profiling by qPCR
Specifications
- Molecular formula
- C26H36N6O9 (free acid); C26H37N7O8 (amide form)
- Molecular weight
- 576.60 g/mol
- Sequence
- Lys-Glu-Asp-Trp
- One-letter code
- KEDW
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- Pancragen; KEDW; Lys-Glu-Asp-Trp; pancreatic peptide bioregulator (literature compound is the amidated KEDW-NH2)
- Supplied as
- 20mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of Pancragen is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
Is Pancragen the free acid or the amide?
Sources differ. The literature compound is described as the amidated form, KEDW-NH2, while the free acid is also listed. Both formulas are given on the product page, so confirm identity by mass spectrometry for quantitative work.
How is Pancragen supplied and stored?
It is supplied as a lyophilised powder in a 20mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is Pancragen a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
