≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
Bronchogen
20mg lyophilised powder
A short bioregulator-type peptide studied in bronchial epithelial cultures for gene expression, proliferation and cell senescence.
£26.90per vial, VAT included
In stock, dispatched same day before 16:00
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- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
Bronchogen is a short bioregulator-type peptide, Ala-Glu-Asp-Leu (AEDL). It is studied in bronchial epithelial cultures for gene expression, proliferation and cell senescence, and belongs to a family of very short peptides described mainly by one research group. Supplied at 20mg as a lyophilised powder for in-vitro laboratory research only.
Bronchogen belongs to the peptide bioregulator family described by the Khavinson group in St Petersburg. These di-, tri- and tetrapeptides are proposed to enter cells and nuclei and to bind specific DNA sequences or histone-associated proteins, changing chromatin state and gene expression in the tissue they were derived from. In bronchial epithelial cell models, Bronchogen has been reported to affect proliferation markers and senescence-associated genes. The mechanisms are hypotheses, and few independent groups have tested them.
Laboratory work uses bronchial epithelial cell lines and primary cultures, with readouts such as proliferation assays, senescence-associated beta-galactosidase staining, qPCR of lung-related genes and immunostaining for epithelial markers. Chromatin accessibility and DNA-peptide binding experiments also appear in the literature. It is supplied as a lyophilised powder in a 20mg vial.
Research areas
- Bronchial epithelial cell proliferation assays
- Senescence markers in cultured cells
- Lung-related gene expression by qPCR
- Peptide-DNA binding and chromatin studies
- Short regulatory peptide uptake
Specifications
- Molecular formula
- C18H30N4O9
- Molecular weight
- 446.45 g/mol
- Sequence
- Ala-Glu-Asp-Leu
- One-letter code
- AEDL
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- Bronchogen; AEDL
- Supplied as
- 20mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of Bronchogen is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What kind of compound is Bronchogen?
It is a four-residue peptide, Ala-Glu-Asp-Leu, from the group of short peptide bioregulators. In that literature it is linked to bronchial tissue, and it is studied for effects on gene expression in epithelial cells.
How is Bronchogen supplied and stored?
It is supplied as a lyophilised powder in a 20mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is Bronchogen a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Longevity and bioregulators
