≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
N-Acetyl Epitalon
10mg lyophilised powder
An acetylated variant of the epitalon tetrapeptide used in telomerase, cell-senescence and gene-regulation studies.
£27.90per vial, VAT included
In stock, dispatched same day before 16:00
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- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
N-Acetyl Epitalon is an acetylated variant of the epitalon tetrapeptide, Ac-Ala-Glu-Asp-Gly (Ac-AEDG), also listed as Ac-Epitalon. It is used in telomerase, cell-senescence and gene-regulation studies in cultured cells, usually alongside the unmodified peptide as a comparator. Supplied at 10mg as a lyophilised powder for in-vitro laboratory research only.
Acetylation of the N-terminus removes the free amino group, a change commonly used to make short peptides more resistant to aminopeptidases and to alter their charge. The parent tetrapeptide has been reported to influence telomerase activity, chromatin structure and gene expression in cultured cells, mostly in work from one research group. Whether the acetylated form behaves the same way has not been widely tested, so comparison with the unmodified peptide is part of the research question.
Laboratory designs run the acetylated and unmodified peptides side by side in fibroblast or epithelial cell lines, measuring telomerase activity by TRAP assay, telomere length, senescence markers and qPCR of regulated genes. Stability in culture media is followed by HPLC and mass spectrometry. It is supplied as a lyophilised powder in a 10mg vial.
Research areas
- Telomerase activity in cultured cells
- Senescence markers and gene regulation
- Effect of N-acetylation on peptide stability
- Side-by-side comparison with unmodified epitalon
- Mass spectrometry of modified tetrapeptides
Specifications
- Molecular formula
- C16H24N4O10
- Molecular weight
- 432.4 g/mol
- Sequence
- Ac-Ala-Glu-Asp-Gly (Ac-AEDG)
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- N-Acetyl Epitalon; N-Acetyl Epithalon; Ac-Epitalon; N-acetylated AEDG (Ac-Ala-Glu-Asp-Gly-OH)
- Supplied as
- 10mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of N-Acetyl Epitalon is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What does N-acetylation change compared with Epithalon?
It adds an acetyl group to the N-terminus of Ala-Glu-Asp-Gly. That removes the free amino group, a change commonly used to increase resistance to aminopeptidases in assay media.
How is it supplied and stored?
It is supplied as a lyophilised powder in a 10mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is N-Acetyl Epitalon a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
