≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
Livagen
20mg lyophilised powder
A four-residue peptide from the Russian 'bioregulator' family, studied for effects on chromatin state and gene expression in lymphocyte and liver-cell models.
£44.90per vial, VAT included
In stock, dispatched same day before 16:00
- Free shipping on UK orders over £20.00
- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
Livagen is a four-residue peptide, Lys-Glu-Asp-Ala (KEDA), from the Russian peptide bioregulator family and listed as a Khavinson family peptide. It is studied for effects on chromatin state and gene expression in lymphocyte and liver-cell models. Supplied at 20mg as a lyophilised powder for in-vitro laboratory research only.
Livagen is described as the liver-associated tetrapeptide of the family. Early reports on cultured lymphocytes described changes in chromatin condensation and in the activity of heterochromatin regions after exposure to the peptide, which led to proposals that it may relax tightly packed chromatin. The same group extended the idea to liver cell models. These results come from a restricted set of laboratories and have seen little independent testing.
In the laboratory, lymphocyte and hepatocyte cell cultures are used, with chromatin condensation measured by microscopy, DNA methylation and histone modification assays, and qPCR of liver-related genes. Peptide-DNA binding assays and mass spectrometry identity checks are common, and uptake of such a short, charged sequence is usually followed with labelled analogues. It is supplied as a lyophilised powder in a 20mg vial.
Research areas
- Chromatin condensation in lymphocyte cultures
- Histone modification and DNA methylation assays
- Hepatocyte gene expression
- Peptide-DNA binding studies
- Identity and purity analysis by HPLC
Specifications
- Molecular formula
- C18H31N5O9
- Molecular weight
- 461.47 g/mol
- Sequence
- Lys-Glu-Asp-Ala
- One-letter code
- KEDA
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- Livagen; KEDA; Lys-Glu-Asp-Ala; peptide bioregulator (Khavinson family)
- Supplied as
- 20mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of Livagen is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What does the Livagen sequence look like?
It is the tetrapeptide Lys-Glu-Asp-Ala (KEDA). It shares the Glu-Asp core found in several related bioregulator peptides, with lysine at the start and alanine at the end.
How is Livagen supplied and stored?
It is supplied as a lyophilised powder in a 20mg vial. Keep it cold, dry and away from light, and reconstitute with a suitable laboratory diluent only when the material is needed.
Is Livagen a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
