≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
FTPP Adipotide
2mg lyophilised powder
A peptide conjugate designed to home to blood vessels in fat tissue, used in studies of adipose vasculature and targeted internalisation.
£24.90per vial, VAT included
In stock, dispatched same day before 16:00
- Free shipping on UK orders over £20.00
- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
FTPP, also called Adipotide, is a synthetic peptide conjugate that pairs a cyclic targeting sequence (CKGGRAKDC) with a pro-apoptotic motif built from D-amino acids. It is used in studies of adipose vasculature and targeted internalisation through prohibitin. Supplied at 2mg as a lyophilised powder for in-vitro laboratory research only.
The targeting sequence is described in the literature as binding prohibitin, which can be displayed on the surface of endothelial cells in certain vascular beds. The second part, a repeated D(KLAKLAK) motif, is an amphipathic sequence that disrupts mitochondrial membranes once the conjugate is taken into a cell. Together they were designed as a targeted pro-apoptotic probe. Published work comes from a small set of groups, and reports in cell and preclinical models should be read with that limit in mind.
Laboratory work includes endothelial cell binding and internalisation assays by fluorescence microscopy, mitochondrial membrane potential and caspase assays, and co-culture experiments with adipocytes and endothelial cells. Competition with free targeting peptide is a standard specificity control. The Cys1-Cys9 disulfide is checked by mass spectrometry. It is supplied as a lyophilised powder.
Research areas
- Prohibitin-targeted cell binding
- Endothelial internalisation by fluorescence microscopy
- Mitochondrial membrane disruption assays
- Caspase and apoptosis readouts
- Adipose vasculature co-culture models
Specifications
- Molecular formula
- C111H204N36O28S2
- Molecular weight
- 2555.2
- Sequence
- Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-[D(Lys-Leu-Ala-Lys-Leu-Ala-Lys)]x2 (CKGGRAKDC-GG-[D(KLAKLAK)]2; Cys1-Cys9 disulfide; D-amino-acid KLAKLAK motif)
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- FTPP, Adipotide, Prohibitin-targeting peptide
- Supplied as
- 2mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent and keep reconstituted material cold.
Certificates of analysis
Each lot of FTPP Adipotide is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What are the two parts of FTPP?
One part is a cyclic targeting sequence, CKGGRAKDC, held by a Cys1-Cys9 disulfide. The other is a D-amino-acid KLAKLAK repeat designed to disrupt mitochondrial membranes after uptake. A GG linker joins them.
How is it supplied and stored?
It is supplied as a lyophilised powder in a 2mg vial. Because of the disulfide bond, keep it cold, dry and away from light, and reconstitute only when the material is needed.
Is FTPP Adipotide a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Metabolic
Studied alongside
