≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
FOXO4
10mg lyophilised powder
A decoy peptide aimed at the FOXO4-p53 interaction, used in cellular senescence research.
£69.99per vial, VAT included
In stock, dispatched same day before 16:00
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- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
FOXO4 here refers to a decoy peptide aimed at the interaction between FOXO4 and p53, also listed as FOXO4-DRI. It is a D-retro-inverso design rather than the full FOXO4 transcription factor, and it is used in cellular senescence research. Supplied at 10mg as a lyophilised powder for in-vitro laboratory research only.
FOXO4 is a transcription factor reported to bind p53 in the nucleus of senescent cells and to keep p53 away from mitochondria, where it would otherwise trigger apoptosis. The decoy peptide mimics the FOXO4 region that contacts p53, and the D-retro-inverso form uses D-amino acids in reverse order to resist proteases while keeping a similar side-chain arrangement. In senescent fibroblast cultures it was reported to release p53 and favour selective apoptosis of senescent cells. Findings come mostly from a few laboratories.
Laboratory work uses cultures in which senescence is induced by irradiation, replicative exhaustion or drug exposure, with proliferating cells as controls. Readouts include senescence-associated beta-galactosidase, p53 localisation by imaging, caspase activation and viability assays. The peptide is large for a decoy and is best checked for solubility on a small scale. It is supplied as a lyophilised powder in a 10mg vial.
Research areas
- Selective apoptosis of senescent cells in culture
- FOXO4-p53 interaction and p53 localisation
- Senescence-associated beta-galactosidase staining
- Caspase activation and viability readouts
- D-retro-inverso peptide design
Specifications
- Molecular formula
- C228H388N86O64
- Molecular weight
- 5358.05 g/mol
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- FOXO4-DRI, FOXO4 inhibitory peptide, FOXO4 decoy peptide
- Supplied as
- 10mg per vial, lyophilised powder
Storage and handling
Store the lyophilised powder in a freezer, protected from moisture and light, and let the vial reach room temperature before opening. Check solubility on a small amount and reconstitute with an appropriate laboratory diluent.
Certificates of analysis
Each lot of FOXO4 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
What does D-retro-inverso mean?
A D-retro-inverso peptide is built from D-amino acids in reverse order. This keeps a similar side-chain layout to the original L-sequence while making the peptide more resistant to proteases, which suits a decoy used in cell culture.
How is it supplied and stored?
It is supplied as a lyophilised powder in a 10mg vial. Keep it cold, dry and away from light, and prepare solutions only when the material is needed.
Is FOXO4 a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
