≥99% HPLCBatch testedIdentity by MS, purity by HPLC
Lot numberedCertificate filed per lot
Cold stored2 to 8 °C until dispatch
Follistatin-344
1mg lyophilised powder
A binding protein for activin and myostatin, used to study TGF-beta superfamily signalling in growth and differentiation.
£44.90per vial, VAT included
In stock, dispatched same day before 16:00
- Free shipping on UK orders over £20.00
- Same day dispatch on orders placed before 16:00
- Batch certificate in the COA Database
Sold for research purposes only. For in-vitro laboratory research. Not a medicine and not for human or animal consumption. Supplied to qualified individuals aged 18 and over; you confirm this at checkout.
Research overview
Follistatin-344 is a protein that binds activin and myostatin, and it is also written FS344 or FST-344. It is studied in TGF-beta superfamily signalling, where it neutralises ligands that regulate growth and differentiation. Supplied at 1mg as a lyophilised powder for in-vitro laboratory research only.
Follistatin is a secreted glycoprotein that binds activins with high affinity and also binds myostatin and related ligands, which keeps them from engaging their cell-surface receptors. By removing free ligand, it reduces Smad2 and Smad3 signalling downstream of the activin receptors. Several follistatin isoforms exist, produced by alternative splicing and processing, and they differ in how strongly they bind cell surfaces, so naming conventions matter when comparing published studies.
Researchers use follistatin in ligand-binding assays, in Smad2/3 reporter assays where it blocks activin- or myostatin-driven signalling, in myoblast and granulosa cell cultures, and as a control when testing other ligand traps. It is a large protein, so aggregation and activity are usually checked before quantitative work. It is supplied as a lyophilised powder.
Research areas
- Activin and myostatin ligand binding
- Smad2/3 signalling blockade in reporter assays
- Myoblast differentiation in culture
- Follistatin isoform comparison
- Ligand-trap controls in TGF-beta pathway studies
Specifications
- Form
- lyophilised powder
- Purity
- ≥99% (HPLC)
- Also known as
- Follistatin 344, FS344, FST-344, activin-binding protein (research designation)
- Supplied as
- 1mg per vial, lyophilised powder
Storage and handling
Store the lyophilised protein cold, dry and protected from light, and let the vial reach room temperature before opening. Reconstitute with an appropriate laboratory diluent, aliquot, and avoid repeated freeze and thaw.
Certificates of analysis
Each lot of Follistatin-344 is released with a certificate recording identity and purity. Enter the lot number printed on your vial on the lab testing page to view it.
Questions
How is follistatin-344 related to ACE-031?
Both bind activin and myostatin family ligands. Follistatin is a naturally occurring ligand-binding protein, while ACE-031 is an engineered fusion of the activin receptor type IIB with an Fc region.
How should the protein be stored?
It is supplied as a lyophilised powder in a 1mg vial. Keep it cold, dry and away from light. After reconstitution, aliquot to limit repeated freezing and thawing.
Is follistatin-344 a medicine?
No. It is supplied strictly for in-vitro laboratory research. It is not a medicine, food or supplement, and it is not for human or animal use. Buyers must be aged 18 or over.
Metabolic
Studied alongside
